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Thr160

WebHuman and Mouse p-CDK2 (Thr160) Detection Kit C ALSU-PCDK2-A500, ALSU-PCDK2-A10K, ALSU-PCDK2-A50K, ALSU-PCDK2-A-HV Kit Specificity This assay kit contains antibodies which recognize the phospho-Thr160 epitope and a distal epitope on CDK2. The protein detected by this kit corresponds to UniProt ID P24941. WebDec 20, 2001 · We examined the role of Thr160 phosphorylation in the recognition of the P + 3 position of the substrate using Cdk2–cyclin A complexes phosphorylated or …

Autocatalytic Phosphorylation of CDK2 at the Activating Thr160

WebJan 17, 2012 · We demonstrated for the first time that monocillin II could arrest breast cancer cell cycle in G1 phase, which might partially be the result of its inhibition effect on the phosphorylation of the Thr160 residue of cyclin dependent kinase 2 (CDK2), a key enzyme in cell-cycle regulation. WebInvitrogen Anti-Phospho-CDK2 (Thr160) Polyclonal, Catalog # PA5-77906. Tested in Western Blot (WB) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This antibody … toward tradition https://enco-net.net

Phospho-CDK2 (Thr160) Antibody Cell Signaling Technology

WebPhospho-CDK2-Thr160 polyclonal antibody (Cyclin-Dependent Kinase 2) binds to endogenous Cyclin-Dependent Kinase 2 at the amino acid region 100-180 only when phosphorylated at Thr160. Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Cdk2/Cdc2 (phospho Thr160) WebApr 10, 2015 · Thr160 of Axin1 is critical for the formation of the Axin1-APC complex. (A) Schematic representations of wild-type Axin1 and Axin1 mutants. (B) Alignment of sequences flanking the Thr160 site in Axin1 proteins from human, mouse and rat. Thr160 (Thr165 in mouse) is indicated in bold. WebApr 12, 2024 · 肾酶(RNLS)重组蛋白说明书. Recombinant Renalase (RNLS) [ PROPERTIES ] Source: Prokaryotic expression. Host: E.coli. Residues: Thr160~Phe319. Tags: N-terminal His Tag toward to用法

Autocatalytic Phosphorylation of CDK2 at the Activating Thr160

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Thr160

Autocatalytic Phosphorylation of CDK2 at the Activating Thr160

Website equivalent to Thr160 in Cdk2 by the Cdk-activating kinase. Much is known about the effects of cyclin binding, but the role of the activating phosphorylation is less well … WebNM_002381.5(MATN3):c.480C>G (p.Thr160=) AND not provided Clinical significance: Likely benign (Last evaluated: Jun 27, 2024) Review status: 1 star out of maximum of 4 stars

Thr160

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WebJan 1, 2006 · The enzymatic activity of the CDK2/Cyclin A complex increases upon the specific phosphorylation of Thr160@CDK2. In the present study, we have performed a …

WebNov 16, 2005 · The models are based on two X-ray structures available for CDK2/CyclinA and pCDK2/CyclinA/Substrate complexes. In this way, we analyze the influence of the phosphorylated Thr160 (pThr160) on both ... WebAbstract. Full activation of cyclin-dependent kinases (Cdks) requires binding to a cyclin and phosphorylation on an activating site equivalent to Thr160 in Cdk2 by the Cdk-activating …

WebIn an activated CDK2, which is phosphorylated at Thr160, the Val164 residue in the activation loop establishes interactions with surrounding residues and adopts an unusual left-handed conformation in order to create a binding pocket to accommodate a trans-conformation proline. WebSpecificity / Sensitivity. Phospho-CDK2 (Thr160) Antibody detects endogenous levels of CDK2 only when phosphorylated at threonine 160. The antibody weakly cross-reacts with …

WebApr 1, 2007 · The kinase activity was dependent on both the catalytic activity of CDK2 and Thr-160 phosphorylation since it was abolished when CDK2 was mutated at Lys33 in the …

WebSpecificity / Sensitivity. Phospho-CDK2 (Thr160) Antibody detects endogenous levels of CDK2 only when phosphorylated at threonine 160. The antibody weakly cross-reacts with … powder coating visual inspection standardsWebSep 1, 2001 · Abstract. Full activation of cyclin-dependent kinases (Cdks) requires binding to a cyclin and phosphorylation on an activating site equivalent to Thr160 in Cdk2 by the Cdk-activating kinase. Much ... toward to 意味WebThe AlphaLISA SureFire Human and Mouse Phospho-CDK2 (Thr160) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-CDK2 (Thr160) in … powder coating voltage mathWebThe .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. powder coating vs anodizingWebJun 26, 2003 · The adenosine 5'-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery program resulting in the discovery of the potent CDK1 and -2 inhibitor NU6102 (3, IC(50) = 9.5 nM and 5.4 nM vs CDK1/cyclinB and CDK2/cyclinA3, … toward traduccionWebMay 1, 2007 · The kinase activity was dependent on both the catalytic activity of CDK2 and Thr-160 phosphorylation since it was abolished when CDK2 was mutated at Lys33 in the ATP binding site (K33R) or Thr160 ... toward to 違いWebApr 10, 2015 · Consistent with these observations, the Axin1 phosphomimetic mutant lost the ability to reduce β-catenin stability and to repress β-catenin/TCF-dependent transcription. Taken together, our results suggest a novel mechanism of Wnt signaling through the dissociation of the β-catenin destruction complex by Axin1 Thr160 modification. toward training pty ltd