WebThe development of photoactivated chemotherapy based on photoresponsive polymers that can be activated by light in the “therapeutic window” would enable new approaches for basic research and allow for anticancer phototherapy in hypoxic conditions. This work synthesizes a novel Ru-containing block copolymer for photoactivated chemotherapy in ... WebAug 14, 2024 · Photoactivated chemotherapy of the polymer micelles demonstrates efficient tumor growth inhibition. In addition, the polymer micelles do not cause any toxic side effects to mice during the treatment, demonstrating good biocompatibility of the system to the blood and healthy tissues. The novel red-light-responsive Ru-containing …
Cancer Care at Mayo Clinic
WebMay 4, 2024 · Photoactivated chemotherapy (PACT) is a new concept that brings these two ideas together. Like PDT , PACT aims at sparing healthy tissues while maintaining toxicity against cancerous cells. Unlike PDT , which often stops working when the concentration of dioxygen in illuminated tissues is too low, light activation of PACT compounds remains ... WebJul 16, 2024 · However, tumor masses often contain hypoxic regions where, owing to the suboptimal vascularization, the concentration of oxygen is remarkably low. 19 Photoactivated chemotherapy has the potential to overcome this limitation. 20 In PACT, light activation of otherwise inert metal complexes, can produce cytotoxic species in a … green cottingham
Why develop photoactivated chemotherapy? - PubMed
WebThe fields of phototherapy and of inorganic chemotherapy both have long histories. Inorganic photoactivated chemotherapy (PACT) offers both temporal and spatial control … WebMay 4, 2024 · Photoactivated chemotherapy (PACT) is a new concept that brings these two ideas together. Like PDT , PACT aims at sparing healthy tissues while maintaining toxicity … WebAug 21, 2024 · Photoactivated chemotherapy is an approach where a biologically active compound is protected against interaction with the cell environment by a light-cleavable … flow vault thornton